XanGo Juice Research – A Continuing Story

The proceding is Part 2 in a two part series by Mike Pugh. Read the first article in the series XanGo Juice Research – The Early Days.

After building a proven standards and measurements system for testing mangosteen and XanGo Juice, we turned our focus into preparations for human clinical studies.

In order to begin human trials, you first have to satisfy government and research committees in regards to the safety of your product. They want to know if you can prove that your product does not cause harm. This means we needed to submit our protocols for human studies, officially called an IRB, to a sanctioned committee. This board looks at safety, efficacy and probability of a positive outcome to the study. They are there to make sure no human is put into a situation that could cause immediate harm or long-term damage.

For two years we prepared for our IRB review. We researched carefully all aspects of XanGo Juice in regards to safety. A big question you will always be asked by the IRB is about the mechanism of action. How does the Juice work once it is consumed? In the science world, it is a little thing we like to call pharmacokinetics. What happens to the xanthones, proanthocyanidins and catechens? What does the liver do to change them or what pathway does it follow (P450 enzymes)? Will it affect the drug pathways? How long do those actives stay in the body?

As we went through our detailed and meticulous safety studies and learned pathways and half- lives we learned some very important facts about XanGo Juice. I am proud to say we only had good things to say about the Juice. Here are just a few results of our two-year study:

• The Juice does not use the common drug pathways. This was a great discovery and of great importance when trying to prove efficacy. It means that XanGo Juice does not interact with any other medications consumed because it doesn’t follow the “common drug pathway” in the body.
• The body’s enzyme levels never really increased or decreased during the study. Another safety measurement that was a good result.
• To keep a constant amount of actives in the blood stream, XanGo Juice should be consumed every four to six hours.

Our paperwork with all our findings was presented to the IRB, reviewed carefully and to no surprise, was approved…we had done our homework. This IRB approval was the launching pad to complete many human clinical trials—some already completed and some to be completed in the future. One completed human study was with Dr. Udani. These positive results have been published and are full of great information. And because of our in-depth study, research and positive results the world-renowned Mayo Clinic has been attracted to our mangosteen juice and is conducting further research. This is an ongoing and in-depth study that will take years to complete, but we are excited to take the first steps. Don’t worry…we’ll keep you posted on its progress and future results.

Throughout this research and as is common in science, more questions were created than answers given. We have come a long way and still have a long way to go in completely understanding mangosteen and all of its beneficial properties. But there is one thing I do know for sure: sitting in a café in Southeast Asia, Joe Morton didn’t just make a single discovery with the mangosteen, but a discovery that has led to discovery upon discovery as each study moves us deeper into the fascinating science behind, and inside, the mangosteen. I am continually amazed and gratefully excited to be a part of it. We already know how mangosteen and XanGo Juice makes us feel, we now have a responsibility to prove it to the entire world so everyone can enjoy the benefits.

3 Responses to “XanGo Juice Research – A Continuing Story”

1. william c harris says:

   August 18, 2010 at 10:56 pm

   as the saying goes, the proof is in the pudding.
2. Diana Greiner says:

   August 19, 2010 at 4:28 pm

   Mike, this is great stuff and very useful, especially for those who have joined XanGo in the past few years and not familiar with the startup (or prestartup) period. Of course, it really confirms what Drs. Templeman and Morton (and others) have been telling us all those years!! Thank you!
3. Kristina says:

   September 9, 2010 at 11:52 pm

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